BIOTECHNOLOGY VALUE FUND L P

• 10% owner at CELL THERAPEUTICS INC · on record since Jun 28, 2023
• 10% owner at PALVELLA THERAPEUTICS, INC. · on record since May 22, 2023
• Director at Olema Pharmaceuticals, Inc. · on record since Jun 21, 2023
• See explanation of responses at Structure Therapeutics Inc. · on record since Feb 13, 2023
• Direct Beneficial Owner at ADVANCED MAGNETICS INC · on record since Jan 13, 2006
• 10% owner at VIACELL INC · on record since Oct 17, 2007
• 10% owner at AEOLUS PHARMACEUTICALS, INC. · on record since Feb 13, 2006
• See Explanation of Responses at enGene Holdings Inc. · on record since Nov 13, 2023
• See Explanation of Responses at Therapeutics Acquisition Corp. · on record since Nov 6, 2023
• Director at Rain Enhancement Technologies Holdco, Inc. · on record since Jan 29, 2024
• See Remarks; Former 10% Owner at Rain Enhancement Technologies Holdco, Inc. · on record since Apr 27, 2021
• See Explanation of Responses at Allakos Inc. · on record since Jan 26, 2024
• See Explanation of Responses at Xenon Pharmaceuticals Inc. · on record since Sep 12, 2016
• See Explanation of Responses at KENT FINANCIAL SERVICES INC · on record since Dec 28, 2011
• Direct Beneficial Owner at ADOLOR CORP · on record since Oct 31, 2008
• Direct Beneficial Owner at VIACELL INC · on record since Nov 26, 2007
• Direct Beneficial Owner at NPS PHARMACEUTICALS INC · on record since Mar 20, 2008
• Direct Beneficial Owner at NEUROBIOLOGICAL TECHNOLOGIES INC /CA/ · on record since Jun 26, 2008
• Direct Beneficial Owner at SGX PHARMACEUTICALS, INC. · on record since Jun 20, 2008
• Direct Beneficial Owner at SUPERGEN INC · on record since May 13, 2008
• Director at IMMUNIC, INC. · on record since Feb 27, 2026
• See Explanation of Responses at IMMUNIC, INC. · on record since Feb 27, 2026
• Direct Beneficial Owner at COMBINATORX, INC · on record since Nov 26, 2008
• Direct Beneficial Owner at AVIGEN INC \DE · on record since Nov 20, 2008
• Direct Beneficial Owner at PHARMACOPEIA DRUG DISCOVERY INC · on record since Nov 7, 2008
• Direct Beneficial Owner at CURIS INC · on record since Apr 29, 2009
• Direct Beneficial Owner at DYNAVAX TECHNOLOGIES CORP · on record since Jun 5, 2009
• 10% owner at CREATIVE VISTAS INC · on record since Jul 11, 2003
• 10% owner at TARGACEPT INC · on record since Jul 13, 2009
• 10% owner at FIRST ALBANY COMPANIES INC · on record since Sep 10, 2009
• Direct Beneficial Owner at REPLIGEN CORP · on record since Jul 8, 2009
• Direct Beneficial Owner at NEUROGEN CORP · on record since Jul 17, 2003
• 10% owner at MEDICINOVA INC · on record since Dec 24, 2009
• Direct Beneficial Owner at ARQULE INC · on record since Jul 22, 2003
• See Footnote 1 at CREATIVE VISTAS INC · on record since Jul 22, 2003
• Direct Beneficial Owner at FIRST ALBANY COMPANIES INC · on record since Jan 29, 2010
• 10% owner at Celera CORP · on record since Mar 23, 2011
• Director at MoonLake Immunotherapeutics · on record since Apr 2, 2026
• 10% owner at MoonLake Immunotherapeutics · on record since Apr 2, 2026
• See Footnote (1) at GENAERA CORP · on record since Sep 5, 2003
• See Explanation of Responses at CAPRIUS INC · on record since Jun 29, 2011
• Direct Beneficial Owner at Celera CORP · on record since Apr 22, 2011
• See Explanation of Responses at NEUROCRINE BIOSCIENCES INC · on record since Oct 14, 2011
• See Explanation of Responses at ICAGEN INC · on record since Sep 9, 2011
• See Explanation of Responses at PALATIN TECHNOLOGIES INC · on record since Oct 7, 2011
• Direct Beneficial Owner at ARENA PHARMACEUTICALS INC · on record since Oct 21, 2003
• Direct Beneficial Owner at BIOCRYST PHARMACEUTICALS INC · on record since Oct 29, 2003
• Direct Beneficial Owner at ARRAY BIOPHARMA INC · on record since Nov 7, 2003
• 10% owner at DISCOVERY PARTNERS INTERNATIONAL INC · on record since Dec 30, 2016
• See Explanation of Responses at TARGACEPT INC · on record since Sep 10, 2012
• See Explanation of Responses at LIGAND PHARMACEUTICALS INC · on record since Jan 25, 2013
• See Explanation of Responses at RIGEL PHARMACEUTICALS INC · on record since May 15, 2013
• 10% owner at XOMA LTD /DE/ · on record since May 18, 2026
• See Explanation of Responses at Oncothyreon Inc. · on record since Jun 7, 2013
• See Footnotes (1)(2) at APPLIED MOLECULAR EVOLUTION INC · on record since Jan 20, 2004
• See Explanation of Responses at ChemoCentryx, Inc. · on record since Sep 13, 2013
• See Explanation of Responses at Regado Biosciences Inc · on record since Mar 25, 2014
• See Footnotes (1) (2) at ZONAGEN INC · on record since Feb 18, 2004
• See Explanation of Responses at CELL THERAPEUTICS INC · on record since Dec 14, 2015
• 10% owner at Oncothyreon Inc. · on record since Jun 27, 2016
• See Explanation of Responses at DISCOVERY PARTNERS INTERNATIONAL INC · on record since Dec 2, 2016
• See Explanation of Responses at XOMA LTD /DE/ · on record since Feb 21, 2017
• See Explanation of Responses at NOVELLUS SYSTEMS INC · on record since Jun 22, 2017
• See Explanation of Responses at GLYCOMIMETICS INC · on record since May 11, 2017
• 10% owner at INSITUFORM TECHNOLOGIES INC · on record since Feb 1, 2005
• See footnote (1) at INSITUFORM TECHNOLOGIES INC · on record since Feb 1, 2005
• See Explanation of Responses at CONCERT PHARMACEUTICALS, INC. · on record since Sep 29, 2017
• See Explanation of Responses at Regulus Therapeutics Inc. · on record since Nov 27, 2017
• 10% owner at ARQULE INC · on record since Oct 20, 2017
• See Explanation of Responses at Syndax Pharmaceuticals Inc · on record since Dec 8, 2017
• See Explanation of Responses at PALVELLA THERAPEUTICS, INC. · on record since Nov 26, 2018
• See Explanation of Responses at Immune Design Corp. · on record since Nov 9, 2018
• See Explanation of Responses at Calithera Biosciences, Inc. · on record since Jul 1, 2019
• See Explanation of Responses at FIVE PRIME THERAPEUTICS INC · on record since Oct 31, 2019
• 10% owner at FIVE PRIME THERAPEUTICS INC · on record since Dec 26, 2019
• See Explanation of Responses at CYTOKINETICS INC · on record since Dec 12, 2019
• See Explanation of Responses at Merus N.V. · on record since Jan 21, 2020
• See Explanation of Responses at IDEAYA Biosciences, Inc. · on record since Jun 22, 2020
• See Explanation of Responses at Principia Biopharma Inc. · on record since Aug 20, 2020
• 10% owner at Merus N.V. · on record since Sep 17, 2020
• See Explanation of Responses at Tokai Pharmaceuticals Inc · on record since Dec 28, 2020
• See Explanation of Responses at CytomX Therapeutics, Inc. · on record since Dec 28, 2020
• See Explanation of Responses at Olema Pharmaceuticals, Inc. · on record since Nov 20, 2020
• 10% owner at Olema Pharmaceuticals, Inc. · on record since Nov 19, 2020
• 10% owner at GLYCOMIMETICS INC · on record since Nov 6, 2020
• See Explanation of Responses at Repare Therapeutics Inc. · on record since Nov 8, 2021
• See Explanation of Responses at Cullinan Therapeutics, Inc. · on record since Jan 10, 2022
• See Explanation of Responses at Verastem, Inc. · on record since Feb 7, 2022
• See Explanation of Responses at 4D Molecular Therapeutics, Inc. · on record since Jun 27, 2022
• Director at XOMA LTD /DE/ · on record since May 20, 2022
• 10% owner at Repare Therapeutics Inc. · on record since Jun 15, 2022
• 10% owner at EPIX Pharmaceuticals, Inc. · on record since Jul 21, 2022
• Director at CELL THERAPEUTICS INC · on record since Aug 11, 2022
• See Explanation of Responses at TF FINANCIAL CORP · on record since Dec 22, 2022
• Director at Kymera Therapeutics, Inc. · on record since Jan 13, 2023
• See Remarks and Footnotes at Kymera Therapeutics, Inc. · on record since Aug 25, 2020