BAKER BROS. ADVISORS LP

• Director at SYNTA PHARMACEUTICALS CORP · on record since Jun 20, 2023
• Former 10% Owner at Atreca, Inc. · on record since Oct 23, 2023
• Former 10% Owner at Neurogene Inc. · on record since Dec 20, 2023
• Former 10% Owner at SEATTLE GENETICS INC /WA · on record since Dec 18, 2023
• 10% owner at Mirati Therapeutics, Inc. · on record since Oct 28, 2013
• Director at vTv Therapeutics Inc. · on record since Mar 7, 2024
• Director at Immunocore Holdings plc · on record since May 29, 2024
• Director at BICYCLE THERAPEUTICS PLC · on record since May 29, 2024
• 10% owner at BICYCLE THERAPEUTICS PLC · on record since May 29, 2024
• 10% owner at Kala Pharmaceuticals, Inc. · on record since Jun 28, 2024
• Director at Kymera Therapeutics, Inc. · on record since Apr 1, 2024
• Director at TScan Therapeutics, Inc. · on record since May 22, 2026
• 10% owner at SERA PROGNOSTICS, INC. · on record since Feb 14, 2025
• Former 10% owner and director at IGM Biosciences, Inc. · on record since Aug 18, 2025
• 10% owner at Celcuity Inc. · on record since Sep 10, 2025
• 10% owner at Kymera Therapeutics, Inc. · on record since Dec 11, 2025
• Former 10% owner at Kala Pharmaceuticals, Inc. · on record since Oct 2, 2025
• Director at INCYTE CORP · on record since Apr 2, 2026
• 10% owner at INCYTE CORP · on record since Apr 2, 2026
• Director at Replimune Group, Inc. · on record since Apr 7, 2026
• 10% owner at Replimune Group, Inc. · on record since Apr 7, 2026
• Director at BeOne Medicines Ltd. · on record since May 27, 2026
• Director at Prelude Therapeutics Inc · on record since Apr 22, 2026
• 10% owner at Prelude Therapeutics Inc · on record since Apr 22, 2026
• Director at INTRABIOTICS PHARMACEUTICALS INC /DE · on record since Apr 24, 2012
• 10% owner at INTRABIOTICS PHARMACEUTICALS INC /DE · on record since Apr 24, 2012
• Director at GENOMIC HEALTH INC · on record since May 23, 2012
• 10% owner at GENOMIC HEALTH INC · on record since May 23, 2012
• 10% owner at XOMA LTD /DE/ · on record since Apr 23, 2012
• 10% owner at BIOCRYST PHARMACEUTICALS INC · on record since Apr 23, 2012
• Director at SEATTLE GENETICS INC /WA · on record since Apr 23, 2012
• 10% owner at SEATTLE GENETICS INC /WA · on record since Apr 23, 2012
• Director at TRIMERIS INC · on record since Apr 23, 2012
• 10% owner at TRIMERIS INC · on record since Apr 23, 2012
• Director at XOMA LTD /DE/ · on record since Oct 31, 2012
• 10% owner at ACADIA PHARMACEUTICALS INC · on record since Dec 21, 2012
• Director at ACADIA PHARMACEUTICALS INC · on record since Jan 23, 2013
• 10% owner at MAYTAG CORP · on record since Jul 11, 2013
• Director at IDERA PHARMACEUTICALS, INC. · on record since Mar 19, 2014
• Director at Kiniksa Pharmaceuticals International, plc · on record since Jun 2, 2026
• Director at Denali Therapeutics Inc. · on record since Jun 5, 2026
• Director at ALEXION PHARMACEUTICALS INC · on record since Jun 30, 2015
• Former 10% owner and Director at TRIMERIS INC · on record since Jun 23, 2015
• 10% owner at Invitae Corp · on record since Aug 27, 2015
• Former 10% owner at XOMA LTD /DE/ · on record since Jul 23, 2015
• 10% owner at Neurogene Inc. · on record since Sep 11, 2015
• 10% owner at BELLICUM PHARMACEUTICALS, INC · on record since Dec 24, 2015
• 10% owner at BeOne Medicines Ltd. · on record since Feb 9, 2016
• Former 10% owner at Intellia Therapeutics, Inc. · on record since May 11, 2016
• 10% owner at Intellia Therapeutics, Inc. · on record since May 5, 2016
• Director at Neurogene Inc. · on record since May 9, 2017
• Former 10% Owner at Mirati Therapeutics, Inc. · on record since Nov 20, 2017
• Former 10% owner at RHYTHM PHARMACEUTICALS, INC. · on record since Oct 6, 2017
• 10% owner at RHYTHM PHARMACEUTICALS, INC. · on record since Oct 4, 2017
• 10% owner at IDERA PHARMACEUTICALS, INC. · on record since Mar 15, 2018
• 10% owner at Kiniksa Pharmaceuticals International, plc · on record since May 31, 2018
• 10% owner at Principia Biopharma Inc. · on record since Sep 13, 2018
• Director at Kodiak Sciences Inc. · on record since Oct 11, 2018
• 10% owner at Kodiak Sciences Inc. · on record since Oct 11, 2018
• 10% owner at Atreca, Inc. · on record since Jun 26, 2019
• Former 10% owner at REDHOOK ALE BREWERY INC · on record since Apr 23, 2019
• 10% owner at REDHOOK ALE BREWERY INC · on record since Apr 18, 2019
• Director at IGM Biosciences, Inc. · on record since Sep 20, 2019
• 10% owner at IGM Biosciences, Inc. · on record since Sep 20, 2019
• Director at SMI PRODUCTS INC · on record since Dec 20, 2019
• 10% owner at SMI PRODUCTS INC · on record since Oct 15, 2019
• Director at Zymeworks Inc. · on record since Mar 16, 2020
• Director at Spyre Therapeutics, Inc. · on record since Feb 25, 2021
• Director at Talis Biomedical Corp · on record since Feb 19, 2021
• 10% owner at Talis Biomedical Corp · on record since Feb 19, 2021
• Director at DBV Technologies S.A. · on record since Jan 11, 2021
• 10% owner at DBV Technologies S.A. · on record since Jan 11, 2021
• 10% owner at TScan Therapeutics, Inc. · on record since Jul 15, 2021
• 10% owner at Entrada Therapeutics, Inc. · on record since Dec 16, 2021