MPM ASSET MANAGEMENT INVESTORS 2003 BVIII LLC

• 10% owner at HELICOS BIOSCIENCES CORP · on record since May 31, 2007
• 10% owner at COTHERIX INC · on record since Jan 10, 2007
• 10% owner at BARRIER THERAPEUTICS INC · on record since Apr 28, 2004
• 10% owner at RIGEL PHARMACEUTICALS INC · on record since Jul 8, 2003
• 10% owner at COMBINATORX, INC · on record since Dec 22, 2009
• 10% owner at CRITICAL THERAPEUTICS INC · on record since May 25, 2004
• 10% owner at MPM ACQUISITION CORP · on record since May 19, 2011
• Former 10% Owner at RIGEL PHARMACEUTICALS INC · on record since Sep 15, 2004
• Former 10% stockholder at MPM ACQUISITION CORP · on record since Sep 29, 2016
• See Remarks at BARRIER THERAPEUTICS INC · on record since Mar 3, 2005