ISIS PHARMACEUTICALS INC

10% owner at Regulus Therapeutics Inc. · on record since Oct 11, 2012
Director at Regulus Therapeutics Inc. · on record since Aug 29, 2014
10% owner at AKCEA THERAPEUTICS, INC. · on record since Jul 21, 2017

Insider trading activity of ISIS PHARMACEUTICALS INC

Transactions on record: 73; since Oct 11, 2012

Open-market buys: 4; $613.5M

Open-market sells: 58; $28.1M

Companies traded: 2; last filing Oct 14, 2020

Figures computed from official regulatory filings — .

Companies where ISIS PHARMACEUTICALS INC has traded

AKCEA THERAPEUTICS, INC.11 tx · $610.5M · Oct 14, 2020
Regulus Therapeutics Inc.62 tx · $31.1M · Jul 17, 2015

Track record of ISIS PHARMACEUTICALS INC

Insufficient history for a statistical track record (fewer than 5 open-market buys).

Transaction history of ISIS PHARMACEUTICALS INC

Co-insiders of ISIS PHARMACEUTICALS INC

CROOKE STANLEY TAKCEA THERAPEUTICS, INC. +1
PARSHALL B LYNNEAKCEA THERAPEUTICS, INC. +1
Aker Christopher RayRegulus Therapeutics Inc.
ALNYLAM PHARMACEUTICALS, INC.Regulus Therapeutics Inc.
Andrews William T.AKCEA THERAPEUTICS, INC.
ASTRAZENECA ABRegulus Therapeutics Inc.
ASTRAZENECA PLCRegulus Therapeutics Inc.
BALTIMORE DAVIDRegulus Therapeutics Inc.
BARRIS PETER JRegulus Therapeutics Inc.
BASKETT FORESTRegulus Therapeutics Inc.
Behbahani AliRegulus Therapeutics Inc.
BIOTECHNOLOGY VALUE FUND II LPRegulus Therapeutics Inc.
BIOTECHNOLOGY VALUE FUND L PRegulus Therapeutics Inc.
Biotechnology Value Trading Fund OS LPRegulus Therapeutics Inc.
Boyce SarahAKCEA THERAPEUTICS, INC.
BVF INC/ILRegulus Therapeutics Inc.
BVF PARTNERS L P/ILRegulus Therapeutics Inc.
BVF Partners OS Ltd.Regulus Therapeutics Inc.
CALSADA CRISPINARegulus Therapeutics Inc.
CARTER BRUCE L ARegulus Therapeutics Inc.
Chang CarmenRegulus Therapeutics Inc.

This page republishes public regulatory disclosures.

Company	Filed	Type	Qty	Price	Value · USD	Signals	Src
AKCEA THERAPEUTICS, INC.Listing unverified	Oct 14, 2020	Buy	21,237,715	18.15 USD	$385.5M	conv 63Unusual sizeFirst in 12mo	SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Dec 19, 2019	Other	6,873,344	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Apr 2, 2019	Other	2,837,373	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Oct 18, 2018	Other	1,671,849	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Aug 6, 2018	Other	1,597,571	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Apr 19, 2018	Buy	10,666,666	18.75 USD	$200M	conv 33	SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Apr 19, 2018	Other	8,000,000	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Jul 21, 2017	Other	28,884,540	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Jul 21, 2017	OtherD (derivative)	-28,884,540	0.00 USD	n/a (Non-cash transaction: the filing states a price of zero (award, gift, exercise))		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Jul 21, 2017	Buy	3,125,000	8.00 USD	$25M	conv 37First in 12mo	SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Jul 21, 2017	Other	13,438,339	—	n/a (No price was disclosed in the filing)		SEC
Regulus Therapeutics Inc.Listing unverified	Jul 17, 2015	Sell	-65,133	10.76 USD	$700.8K		SEC
Regulus Therapeutics Inc.Listing unverified	Jul 17, 2015	Sell	-111,000	10.21 USD	$1.1M		SEC
Regulus Therapeutics Inc.Listing unverified	Jul 17, 2015	Sell	-167,000	10.79 USD	$1.8M		SEC
Regulus Therapeutics Inc.Listing unverified	Jul 2, 2015	Sell	-13,248	10.79 USD	$142.9K		SEC
Regulus Therapeutics Inc.Listing unverified	Jul 2, 2015	Gift	13,248	0.00 USD	n/a (Non-cash transaction: the filing states a price of zero (award, gift, exercise))		SEC
Regulus Therapeutics Inc.Listing unverified	Nov 5, 2014	Sell	-1,279,411	15.94 USD	$20.4M	Unusual size	SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-450	14.90 USD	$6.7K		SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-11,376	16.59 USD	$188.7K	Unusual size	SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-1,054	14.63 USD	$15.4K		SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-15,791	12.83 USD	$202.6K	Unusual size	SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-9,283	12.18 USD	$113.1K	Unusual size	SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-350	15.50 USD	$5.4K		SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-57,753	13.91 USD	$803.3K	Unusual size	SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-446	16.29 USD	$7.3K		SEC

Company	Filed	Type	Qty	Price	Value · USD	Signals	Src
AKCEA THERAPEUTICS, INC.Listing unverified	Oct 14, 2020	Buy	21,237,715	18.15 USD	$385.5M	conv 63Unusual sizeFirst in 12mo	SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Dec 19, 2019	Other	6,873,344	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Apr 2, 2019	Other	2,837,373	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Oct 18, 2018	Other	1,671,849	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Aug 6, 2018	Other	1,597,571	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Apr 19, 2018	Buy	10,666,666	18.75 USD	$200M	conv 33	SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Apr 19, 2018	Other	8,000,000	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Jul 21, 2017	Other	28,884,540	—	n/a (No price was disclosed in the filing)		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Jul 21, 2017	OtherD (derivative)	-28,884,540	0.00 USD	n/a (Non-cash transaction: the filing states a price of zero (award, gift, exercise))		SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Jul 21, 2017	Buy	3,125,000	8.00 USD	$25M	conv 37First in 12mo	SEC
AKCEA THERAPEUTICS, INC.Listing unverified	Jul 21, 2017	Other	13,438,339	—	n/a (No price was disclosed in the filing)		SEC
Regulus Therapeutics Inc.Listing unverified	Jul 17, 2015	Sell	-65,133	10.76 USD	$700.8K		SEC
Regulus Therapeutics Inc.Listing unverified	Jul 17, 2015	Sell	-111,000	10.21 USD	$1.1M		SEC
Regulus Therapeutics Inc.Listing unverified	Jul 17, 2015	Sell	-167,000	10.79 USD	$1.8M		SEC
Regulus Therapeutics Inc.Listing unverified	Jul 2, 2015	Sell	-13,248	10.79 USD	$142.9K		SEC
Regulus Therapeutics Inc.Listing unverified	Jul 2, 2015	Gift	13,248	0.00 USD	n/a (Non-cash transaction: the filing states a price of zero (award, gift, exercise))		SEC
Regulus Therapeutics Inc.Listing unverified	Nov 5, 2014	Sell	-1,279,411	15.94 USD	$20.4M	Unusual size	SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-450	14.90 USD	$6.7K		SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-11,376	16.59 USD	$188.7K	Unusual size	SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-1,054	14.63 USD	$15.4K		SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-15,791	12.83 USD	$202.6K	Unusual size	SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-9,283	12.18 USD	$113.1K	Unusual size	SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-350	15.50 USD	$5.4K		SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-57,753	13.91 USD	$803.3K	Unusual size	SEC
Regulus Therapeutics Inc.Listing unverified	Oct 28, 2014	Sell	-446	16.29 USD	$7.3K		SEC