Domain Partners VI, L.P.

• 10% owner at Vanda Pharmaceuticals Inc. · on record since Apr 18, 2006
• 10% owner at Somaxon Pharmaceuticals, Inc. · on record since Sep 14, 2006
• 10% owner at CADENCE PHARMACEUTICALS INC · on record since Oct 30, 2006
• 10% owner at ALIMERA SCIENCES INC · on record since Apr 27, 2010
• 10% owner at ZOGENIX, INC. · on record since Nov 22, 2010
• 10% owner at Celator Pharmaceuticals Inc · on record since Jan 15, 2013
• 10% owner at TRANZYME INC · on record since Jul 31, 2013
• 10% owner at Regado Biosciences Inc · on record since Aug 28, 2013
• 10% owner at Aldeyra Therapeutics, Inc. · on record since May 7, 2014
• 10% owner at MARINUS PHARMACEUTICALS INC · on record since Jul 31, 2014
• 10% owner at CoLucid Pharmaceuticals, Inc. · on record since May 11, 2015
• 10% owner at Syndax Pharmaceuticals Inc · on record since Mar 8, 2016