Apple Tree Partners IV, L.P.

• 10% owner at TITAN PHARMACEUTICALS INC · on record since Dec 4, 2013
• Director at Tokai Pharmaceuticals Inc · on record since Sep 24, 2014
• 10% owner at Tokai Pharmaceuticals Inc · on record since Sep 24, 2014
• Director at ADVANCE TECHNOLOGIES INC · on record since Oct 20, 2015
• 10% owner at ADVANCE TECHNOLOGIES INC · on record since Oct 20, 2015
• 10% owner at Akero Therapeutics, Inc. · on record since Jun 25, 2019
• 10% owner at Stoke Therapeutics, Inc. · on record since Jun 21, 2019