Opaleye Management Inc.

Former 10% Owner. at TELA Bio, Inc. · on record since Apr 20, 2023
10% owner at CODEXIS, INC. · on record since Sep 26, 2024
10% owner at SANUWAVE Health, Inc. · on record since Apr 21, 2026
10% owner at Sol-Gel Technologies Ltd. · on record since May 14, 2026
10% owner at Alpha Cognition Inc. · on record since May 19, 2026
10% owner at HARROW, INC. · on record since Jun 30, 2015
10% owner at Grace Therapeutics, Inc. · on record since Aug 19, 2026
10% owner at OCULAR THERAPEUTIX, INC · on record since Dec 27, 2019
10% owner at Eton Pharmaceuticals, Inc. · on record since Apr 6, 2020
Previously a 10% owner at OCULAR THERAPEUTIX, INC · on record since Apr 3, 2020
10% owner at Tracon Pharmaceuticals, Inc. · on record since Aug 31, 2020
10% owner at Protara Therapeutics, Inc. · on record since Sep 25, 2020
10% owner at TELA Bio, Inc. · on record since Jun 30, 2022

Insider trading activity of Opaleye Management Inc.

Transactions on record: 539; since May 20, 2015

Open-market buys: 399; $69.7M

Open-market sells: 137; $41.6M

Companies traded: 11; last filing Oct 2, 2026

Figures computed from official regulatory filings — .

Companies where Opaleye Management Inc. has traded

Grace Therapeutics, Inc.9 tx · $104.2K · Oct 5, 2026
Alpha Cognition Inc.54 tx · $7.7M · Oct 2, 2026
Sol-Gel Technologies Ltd.49 tx · $11.2M · Sep 14, 2026
57 tx · $20.8M · Jul 17, 2026
19 tx · $2.9M · May 4, 2026
80 tx · $24.1M · Mar 5, 2026
71 tx · $21.3M · Dec 15, 2025
73 tx · $8.6M · Sep 12, 2024
89 tx · $12.8M · Nov 14, 2023
38 tx · $4M · Nov 4, 2022
3 tx · $137.9K · Jan 3, 2020

Track record of Opaleye Management Inc.

Statistical track record

Free account

Open-market buys: 400

Last buy: Oct 1, 2026

Win rates, median returns and the proven-insider analysis come with a free account.

Transaction history of Opaleye Management Inc.

Co-insiders of Opaleye Management Inc.

This page republishes public regulatory disclosures.

Company	Filed	Type	Qty	Price	Value · USD	Signals	Src
Grace Therapeutics, Inc.Listing on record	Oct 5, 2026	Buy	38,796	2.04 USD	$79K		SEC
Grace Therapeutics, Inc.Listing on record	Oct 5, 2026	Buy	20,000	2.07 USD	$41.4K		SEC
Grace Therapeutics, Inc.Listing on record	Oct 5, 2026	Buy	1,694	2.06 USD	$3.5K		SEC
Alpha Cognition Inc.Listing unverified	Oct 2, 2026	Buy	19,050	8.69 USD	$165.6K	conv 23	SEC
Grace Therapeutics, Inc.Listing on record	Oct 1, 2026	Buy	5,318	2.10 USD	$11.2K	conv 29	SEC
Grace Therapeutics, Inc.Listing on record	Oct 1, 2026	Buy	9,771	2.10 USD	$20.5K	conv 29	SEC
Grace Therapeutics, Inc.Listing on record	Oct 1, 2026	Buy	7,849	2.09 USD	$16.4K	conv 29	SEC
Alpha Cognition Inc.Listing unverified	Sep 28, 2026	Buy	18,337	8.57 USD	$157.1K	conv 20	SEC
Alpha Cognition Inc.Listing unverified	Sep 28, 2026	Buy	13,426	8.47 USD	$113.7K	conv 20	SEC
Alpha Cognition Inc.Listing unverified	Sep 16, 2026	Buy	3,375	8.54 USD	$28.8K	conv 19	SEC
Alpha Cognition Inc.Listing unverified	Sep 16, 2026	Buy	40,373	8.70 USD	$351.1K	conv 24	SEC
Alpha Cognition Inc.Listing unverified	Sep 16, 2026	Buy	27,141	8.40 USD	$228K	conv 20	SEC
Alpha Cognition Inc.Listing unverified	Sep 16, 2026	Buy	53,029	8.57 USD	$454.6K	conv 27	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 14, 2026	Buy	1,493	65.95 USD	$98.5K	conv 25	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 14, 2026	Buy	1,631	66.80 USD	$108.9K	conv 25	SEC
Grace Therapeutics, Inc.Listing on record	Sep 10, 2026	Buy	5,836	2.09 USD	$12.2K	conv 29	SEC
Grace Therapeutics, Inc.Listing on record	Sep 10, 2026	Buy	9,393	2.10 USD	$19.7K	conv 29	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 9, 2026	Buy	2,100	68.98 USD	$144.9K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 9, 2026	Buy	918	69.52 USD	$63.8K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 9, 2026	Buy	3,097	68.71 USD	$212.8K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 9, 2026	Buy	471	69.37 USD	$32.7K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 9, 2026	Buy	3,390	68.74 USD	$233K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 3, 2026	Buy	900	68.95 USD	$62.1K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 3, 2026	Buy	783	69.52 USD	$54.4K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Aug 31, 2026	Buy	10,000	71.40 USD	$714K	conv 39	SEC

Company	Filed	Type	Qty	Price	Value · USD	Signals	Src
Grace Therapeutics, Inc.Listing on record	Oct 5, 2026	Buy	38,796	2.04 USD	$79K		SEC
Grace Therapeutics, Inc.Listing on record	Oct 5, 2026	Buy	20,000	2.07 USD	$41.4K		SEC
Grace Therapeutics, Inc.Listing on record	Oct 5, 2026	Buy	1,694	2.06 USD	$3.5K		SEC
Alpha Cognition Inc.Listing unverified	Oct 2, 2026	Buy	19,050	8.69 USD	$165.6K	conv 23	SEC
Grace Therapeutics, Inc.Listing on record	Oct 1, 2026	Buy	5,318	2.10 USD	$11.2K	conv 29	SEC
Grace Therapeutics, Inc.Listing on record	Oct 1, 2026	Buy	9,771	2.10 USD	$20.5K	conv 29	SEC
Grace Therapeutics, Inc.Listing on record	Oct 1, 2026	Buy	7,849	2.09 USD	$16.4K	conv 29	SEC
Alpha Cognition Inc.Listing unverified	Sep 28, 2026	Buy	18,337	8.57 USD	$157.1K	conv 20	SEC
Alpha Cognition Inc.Listing unverified	Sep 28, 2026	Buy	13,426	8.47 USD	$113.7K	conv 20	SEC
Alpha Cognition Inc.Listing unverified	Sep 16, 2026	Buy	3,375	8.54 USD	$28.8K	conv 19	SEC
Alpha Cognition Inc.Listing unverified	Sep 16, 2026	Buy	40,373	8.70 USD	$351.1K	conv 24	SEC
Alpha Cognition Inc.Listing unverified	Sep 16, 2026	Buy	27,141	8.40 USD	$228K	conv 20	SEC
Alpha Cognition Inc.Listing unverified	Sep 16, 2026	Buy	53,029	8.57 USD	$454.6K	conv 27	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 14, 2026	Buy	1,493	65.95 USD	$98.5K	conv 25	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 14, 2026	Buy	1,631	66.80 USD	$108.9K	conv 25	SEC
Grace Therapeutics, Inc.Listing on record	Sep 10, 2026	Buy	5,836	2.09 USD	$12.2K	conv 29	SEC
Grace Therapeutics, Inc.Listing on record	Sep 10, 2026	Buy	9,393	2.10 USD	$19.7K	conv 29	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 9, 2026	Buy	2,100	68.98 USD	$144.9K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 9, 2026	Buy	918	69.52 USD	$63.8K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 9, 2026	Buy	3,097	68.71 USD	$212.8K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 9, 2026	Buy	471	69.37 USD	$32.7K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 9, 2026	Buy	3,390	68.74 USD	$233K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 3, 2026	Buy	900	68.95 USD	$62.1K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Sep 3, 2026	Buy	783	69.52 USD	$54.4K	conv 24	SEC
Sol-Gel Technologies Ltd.Listing on record	Aug 31, 2026	Buy	10,000	71.40 USD	$714K	conv 39	SEC