Baker Bros. Advisors (GP) LLC

USReporting entityDirector

Transactions

405

Issuers

Buys / Sells

187/62

Last tx

12 Nov 2025

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Insider

Baker Bros. Advisors (GP) LLC

USReporting entityDirector12 companies · 24mo

Transactions

405

Issuers

Buys / Sells

187/62

Last tx

12 Nov 2025

Behaviour

2 purchases reported after at least 12 months of silence — most recent on 13 Dec 2024.

Current positions

Holdings derived from the most recent reported transactions. Not adjusted for stock splits or share-class conversions.

Issuer	Shares	Source	Last tx	Detail
XOMA Royalty Corp	16,516,549	reported	16 Dec 2014	tx 9−1,033,800
Kodiak Sciences Inc.	15,796,955	reported	06 Jun 2022	tx 26+761,505
BIOCRYST PHARMACEUTICALS INC	12,849,240	reported	04 Feb 2016	tx 10+659,410
Kymera Therapeutics, Inc.	6,117,295	reported	30 Jun 2025	tx 4+1,311,000
Entrada Therapeutics, Inc.	4,653,430

Track record

Average stock performance after each discretionary buy, measured at 1, 3 and 6 months. 86 buys in history.

1 month

+9.4%

Sample86

Win rate (≥5%)65%

Hit rate (>0)74%

3 months

+25.9%

Sample86

Win rate (≥5%)86%

Hit rate (>0)88%

6 months

+43.3%

Sample86

Win rate (≥5%)60%

Hit rate (>0)69%

Recent transactions

Date	Type	Issuer	Qty	Price
10 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	2,947	7.22 USD
12 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	11,494	7.95 USD
11 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	11,701	7.39 USD
11 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	2,795	7.54 USD
11 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	30,879	7.54 USD
12 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	7,321	7.73 USD
12 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	80,881	7.73 USD
12 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	1,040	7.95 USD
10 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	267	7.22 USD
10 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	25,364	7.21 USD
10 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	2,296	7.21 USD
11 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	1,059	7.39 USD
08 Sept 2025	PURCHASE	Celcuity Inc.	151,524	56.22 USD
08 Sept 2025	PURCHASE	Celcuity Inc.	4,212	58.02 USD
08 Sept 2025	PURCHASE	Celcuity Inc.	388	58.02 USD
08 Sept 2025	PURCHASE	Celcuity Inc.	13,976	56.22 USD
18 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	2,460	372.87 USD
18 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	26,704	372.87 USD
18 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	675	374.43 USD
18 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	7,325	374.43 USD
20 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	480	380.44 USD
20 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	5,209	380.44 USD
20 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	176	380.78 USD
20 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	1,919	380.78 USD
20 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	873	381.12 USD

Track record

Average stock performance after each discretionary buy, measured at 1, 3 and 6 months. 86 buys in history.

1 month

+9.4%

Sample86

Win rate (≥5%)65%

Hit rate (>0)74%

3 months

+25.9%

Sample86

Win rate (≥5%)86%

Hit rate (>0)88%

6 months

+43.3%

Sample86

Win rate (≥5%)60%

Hit rate (>0)69%

Current positions

Holdings derived from the most recent reported transactions. Not adjusted for stock splits or share-class conversions.

Issuer	Shares	Source	Last tx	Detail
XOMA Royalty Corp	16,516,549	reported	16 Dec 2014	tx 9−1,033,800
Kodiak Sciences Inc.	15,796,955	reported	06 Jun 2022	tx 26+761,505
BIOCRYST PHARMACEUTICALS INC	12,849,240	reported	04 Feb 2016	tx 10+659,410
Kymera Therapeutics, Inc.	6,117,295	reported	30 Jun 2025	tx 4+1,311,000
Entrada Therapeutics, Inc.	4,653,430

Recent transactions

Date	Type	Issuer	Qty	Price
10 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	2,947	7.22 USD
12 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	11,494	7.95 USD
11 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	11,701	7.39 USD
11 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	2,795	7.54 USD
11 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	30,879	7.54 USD
12 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	7,321	7.73 USD
12 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	80,881	7.73 USD
12 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	1,040	7.95 USD
10 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	267	7.22 USD
10 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	25,364	7.21 USD
10 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	2,296	7.21 USD
11 Nov 2025	PURCHASE	Entrada Therapeutics, Inc.	1,059	7.39 USD
08 Sept 2025	PURCHASE	Celcuity Inc.	151,524	56.22 USD
08 Sept 2025	PURCHASE	Celcuity Inc.	4,212	58.02 USD
08 Sept 2025	PURCHASE	Celcuity Inc.	388	58.02 USD
08 Sept 2025	PURCHASE	Celcuity Inc.	13,976	56.22 USD
18 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	2,460	372.87 USD
18 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	26,704	372.87 USD
18 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	675	374.43 USD
18 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	7,325	374.43 USD
20 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	480	380.44 USD
20 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	5,209	380.44 USD
20 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	176	380.78 USD
20 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	1,919	380.78 USD
20 Aug 2025	PURCHASE	MADRIGAL PHARMACEUTICALS, INC.	873	381.12 USD