| Date | Type | Insider | Qty | Price | Signals |
|---|---|---|---|---|---|
| 09 Nov 2007 | SALE | BVF INVESTMENTS LLCentity | 4,471,000 | 7.25 USD | indirect |
| 09 Nov 2007 | SALE | BVF INVESTMENTS LLCentity | 1,151,000 | 7.25 USD | indirect |
| 09 Nov 2007 | SALE | BVF INVESTMENTS LLCentity | 1,683,900 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM BIOVENTURES PARALLEL FUND L Pentity | 46,089 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM BIOVENTURES PARALLEL FUND L Pentity | 5,012,274 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM BIOVENTURES PARALLEL FUND L Pentity | 130,880 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM BIOVENTURES PARALLEL FUND L Pentity | 14,444 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM BIOVENTURES PARALLEL FUND L Pentity | 25,283 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM BIOVENTURES PARALLEL FUND L Pentity | 335,628 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM BIOVENTURES PARALLEL FUND L Pentity | 2,715 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM Founders LLCentity | 14,444 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM Founders LLCentity | 335,628 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM Founders LLCentity | 25,283 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM Founders LLCentity | 5,012,274 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM Founders LLCentity | 130,880 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM Founders LLCentity | 46,089 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM Founders LLCentity | 2,715 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM Founders LLCentity | 41,146 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM ASSET MANAGEMENT II LLCentity | 335,628 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM ASSET MANAGEMENT II LLCentity | 25,283 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM ASSET MANAGEMENT II LLCentity | 14,444 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM ASSET MANAGEMENT II LLCentity | 5,012,274 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM ASSET MANAGEMENT II LLCentity | 130,880 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM ASSET MANAGEMENT II LLCentity | 46,089 | 7.25 USD | indirect |
| 09 Nov 2007 | TENDER | MPM ASSET MANAGEMENT II LLCentity | 2,715 | 7.25 USD | indirect |